Biceps Tendon Rupture With Post-operative Complications

Biceps Tendon Rupture With Post-operative ComplicationsLocomotor PBL Experiment WriteupIntroductionIn this PBL, we observe a case of biceps tendon rupture with post-operative leg of heterotopic compliance. We will first go through the anatomy of the upper limb followed by a discussion of the ruptured biceps tendon, heterotopic ossification and finally mode of action of indomethacin. information Objectives1. Osteology of the upper limb with emphasis on the shove and articulatio radiocarpea2. The neurovascular supply to the upper limb3. Movements feasible at joints of upper limb and the range of movements possible with regards to the articulatio cubiti and wrist and the muscles that bring about these actions.4. Rupture of distal biceps tendon5. Heterotopic ossification6. Mode of action of Indomethacin1. Osteology of the upper limb with emphasis on the elbow and wristArmThe humerus is the largest and longest raise of the arm region connecting the shoulder to the forearm. Proximal ly, the head of the humerus articulates with the glenoid cavity of the scapula forming the glenohumeral joint. Distally the humerus articulates with the two tog ups of the forearm, the elbow bone and radius. The humerus is shown in more detail in figure 1 below.Figure 1 Humerus (1)For anils case we will focus several expectant features on the distal region of the humerus which forms part of the elbow. thither argon two projections on either side of the distal end of the humerus which are the medial and squint epicondyle. The medial epicondyle protects the elbow boner gist which passes just posteriorly and also serves as the attachment billet for the forearm superficial flexor muscles. The lateral epicondyle conversely is the attachment site for the forearm extensor muscles. Anteriorly in between these two epicondyles are two articular surfaces the round surfaced lateral capitulum which articulates with the radius and the spool cause medial trochlea which articulates with the ulna. Also anteriorly, the radial-ply tire-ply tire stone pit directly above the capitulum accommodates the head of the radius during flexion of the elbow whereas the coronoid fossa directly above the trochlea accommodates the coronoid handle of the ulna during flexion of the elbow. Both the radial and coronoid fossa limit flexion of the elbow. Posteriorly, the olecranon fossa accommodates the olecranon process of the ulna during extension of the elbow. The olecranon fossa prevents hyperextension of the elbow.ForearmThe forearm is made up of two bones ulna and radius. Proximally both of these bones articulate with the humerus whereas distally only the radius directly articulates with the carpals of the wrist thus connecting the arm to the wrist. The ulna and radius are shown in figure 2 below.Figure 2 Radius and Ulna (1)The ulnaThe ulna is the stabilise bone of the forearm and is medial and longer of the two bones. There is a projection anteriorly at the proximal end called the coronoid process which fits into the coronoid fossa during elbow extension. Posteriorly on the proximal end of the ulna is the olecranon process (which forms the prominence of the elbow) which fits into the olecranon fossa during elbow extension. The articular surface between the olecranon and the coronoid articulates with the trochlear of the humerus and gives the movements of elbow extension and flexion.The radiusThe radius is the lateral and shorter of the two bones. The head of the radius is a flat button shaped process that articulates with the capitulum of the humerus. The distinguish of the radius is a constriction just distal to the head which Anil has fractured. Due to the fact that no neurovascular problems were found, it is safe to conclude that the deep branch of the radial nerve was not damaged in this case. The radial tuberosity is distal to the neck on the anterior site which is the attachment point for the tendon of biceps. wristThe ulna does not directly articulat e with the carpal bones of the wrist distally. There is an articular disc between the smaller distal head of the ulna and the carpal bones. The radius directly articulates with the scaphoid and lunate carpal bones on its larger distal end. This is shown in figure 3 below.Figure 3 Wrist joint (1)2 The neurovascular supply of the upper limbarterial supplyThe upper limb is supplied by the subclavian arteria which branches off from the brachiocephalic proboscis on the right and aortic arch on the left. The subclavian artery extends from its origin to the lateral border of the first rib. It therefore changes its name to the axillary artery which extends to the lateral border of teres major after which it becomes the brachial artery. The brachial artery extends to the cubital fossa of the elbow where it bifurcates into the radial and ulnar artery which obtain down the lateral and medial side of the forearm respectively. These two arteries anastomose in the palm of the hand forming the superficial (mainly supplied by ulnar artery) and deep (mainly supplied by radial artery) palmar arches. The fingers are supplied by the digital arteries branching from the palmar arches. The arterial supply is illustrated in figure 4 below.Figure 4 Arterial supply of upper limb (2)Venous supplyThere are two main types of veins in the upper limb. Firstly, superficial veins which can be seen subcutaneously. There are three main superficial veins which are the cephalic (laterally), basilic (medially) and median cubital (connection between cephalic and basilica at the cubital fossa) veins. The superficial veins are shown in figure 5 below.Figure 5 Venous supply to upper limb (3)Secondly, there are deep veins which usually accompanies the arteries in pairs and take in the same name as the arteries. Perforating veins connect the superficial and deep veins to allow blood to always find a way back to the heart. All the veins at last drains into the axillary vein, then to the subclavian vein, then brachiocephalic vein and finally into the heart via superior vena cava.Nervous supplyThe brachial plexus serves as the nerve supply for the upper limb arising from spinal nerve roots from C5, 6, 7, 8 and T1. There are 5 terminal branches of the brachial plexus in the arm. circuit card 1 below shows the five terminal nerves with their corresponding roots, motor supply, sensorial supply and clinical test.Table 1 Nerves, corresponding roots, motor supply, sensory supply and clinical test (4)3 Movements possible at joints of upper limb and the range of movements possible with regards to the elbow and wrist and the muscles that bring about these actions.The elbow consists of three joints the humeroulnar joint from the trochlear notch of the ulnar to trochlear of humerus, the humeroradial joint from the head of the radius to the capitulum of humerus and the superior radioulnar joint from the head of the radius to the radial notch of the ulna. The humeroulnar and humeroradial joints allow for flexion and extension of the elbow whereas the superior radioulnar joint allows for pronation and supination. This happens when the head of the radius which is enclosed in annular ligament crosses oer the fixed ulna bone.The muscles that move the elbow are shown in table 2 belowTable 2 Main muscles of elbow (5)Movements and ranges for the elbow and wrist are shown in table 3 belowTable 3 Movements and ranges for elbow and wrist (6)4 Rupture of distal biceps tendonSymptomsSymptoms include swelling in the expect of the elbow, severe pain at the elbow and a bulge in the upper arm because of the shortened biceps brachii muscle. Since Anil shows no biceps tendon reflex upon assessment, this is belike to be a complete rupture of the tendon.CauseIn this case, Anil is diagnosed to have ruptured his distal biceps tendon which attaches to the radial tuberosity. Distal biceps tendon rupture tends to be caused by a single traumatic event involving flexion of the elbow at a ri ght angle against resistance. For Anil, the snapping of the rope caused his elbow to straighten suddenly. His biceps contract extra hard to prevent this from happening but the extreme tension in his biceps and tendon led to the rupture of the distal biceps tendon.TreatmentSince Anil is soundless relatively young at 38 years old and still needs full use of his upper limb, the functional interference option is close preferred. Sometimes the tendon is attached by stitching through holes made in the bone. However the surgery for Anil was done by attaching the tendon to the bone using a small metal plate and screws into the radius to secure the plate usually called the endobutton proficiency (7, 8) which has a very good prognosis of riposte full mobility in the elbow.ComplicationsComplications after the surgery include nerve damage and heterotopic ossification. After eight weeks Anil returned with stiffness, difficulty in turning his hand over and wrist pain which the doctor diagnos ed as heterotopic ossification after palpation of a firm mass along the biceps tendon. Direct intervention was not taken as the biceps tendon needed time to fully heal.5 Heterotopic ossificationHeterotopic ossification is the growth of bone in abnormal places such as aristocratic tissue. Heterotopic ossification is a notable complication of distal biceps tendon repair. The current proposed pathogenesis of how heterotopic ossification arises is the transformation of pluripotential mesenchymal cells which are recruited to the fracture healing site into osteoblasts that results in ectopic bone formation. (9) Bone, tendons and ligaments which are all connective tissue all share the same mesenchymal ascendent cell origin (shown in figure 6) and thus mesenchymal idea cells recruited to promote tendon repair can differentiate into osteoblasts. Osteoblasts can also be pulled out of the bone when the tendon ruptures and therefore can lead to bone deposition. Hence great attention has bee n given to cleaning and irrigating the surgical zone. (10)Figure 6 Mesenchymal stem cells differentiation (11)The heterotopic ossification at the biceps tendon led to Anil having reduced supination to just 20 due to the biceps being the main supinator muscle. After twenty weeks, the heterotopic ossification was surgically removed.Radiation therapy has been an established supplement in treatment of heterotopic ossification. (10, 12, 13) The mechanism of how radiation therapy works is still unclear but is thought to inhibit pluripotential mesenchymal stem cells from differentiating. (14) However, even though radiation therapy is effective, there has been concerns about malignity from the radiation. Low doses (6 Mode of action of IndomethacinNon-steroidal anti-inflammatory drugs (NSAID) such as Indomethacin are also commonly used to supplement surgical excision of heterotopic ossifications. (10, 13) Indomethacin non-selectively inhibits cyclooxygenase (COX1 and COX 2) which are involv ed in the production of prostaglandins from arachidonic acid. During the healing of a fracture, mesenchymal stem cells differentiate into chondrocytes which is independent of COX-2. COX-2 then produces prostaglandins which cause the chondrocytes to hypertrophy. These hypertrophic cells secrete growth factors which cause angiogenesis, osteoclast recruitment, osteogenesis and fracture bridging which leads to bone deposition shown in figure 7 below. However NSAIDs have to be carefully decreed especially with patients who have reflux diseases as NSAIDs can lead to ulcer formation. (19)Figure 7 Formation of bone via COX-2 and prostaglandins (20)In conclusion, more investigate has to be done into the pathophysiology of heterotopic ossification as well as selective drugs that only inhibit COX-2 so that NSAIDs can be safely electropositive even for patients who have reflux diseases.Bibliography1.N. 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